HAMP
hepcidin antimicrobial peptide
Sinónimos:
HEPC, HFE2B, LEAP1, PLTR
Especie:
Human HAMP (57817), Mouse Hamp (84506), Rat Hamp (84604), naked mole-rat Hamp (101700964), domestic guinea pig Hamp (100733490), domestic cat HAMP (101084332), dog HAMP (492281), cow HAMP (512301), Horse HAMP (100050728), sheep HAMP (100500730)
ID UniProtKB:
ID del gen:
- Human(57817) Summary: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]
- Mouse(84506) hepcidin antimicrobial peptide
- Rat(84604) hepcidin antimicrobial peptide
- naked mole-rat(101700964) hepcidin antimicrobial peptide
- domestic guinea pig(100733490) hepcidin antimicrobial peptide
- domestic cat(101084332) hepcidin antimicrobial peptide
- dog(492281) hepcidin antimicrobial peptide
- cow(512301) hepcidin antimicrobial peptide
- Horse(100050728) hepcidin antimicrobial peptide
- sheep(100500730) hepcidin antimicrobial peptide
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