EDN3
endothelin 3
Sinónimos:
ET-3, ET3, HSCR4, PPET3, WS4B
Especie:
Human EDN3 (1908), Mouse Edn3 (13616), Rat Edn3 (366270), cow EDN3 (513753), naked mole-rat Edn3 (101722729), dog EDN3 (403406), chicken EDN3 (768509), Horse EDN3 (100034064), sheep EDN3 (101114458), domestic guinea pig Edn3 (100733839)
ID UniProtKB:
ID del gen:
- Human(1908) Summary: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(13616) endothelin 3
- Rat(366270) endothelin 3
- cow(513753) endothelin 3
- naked mole-rat(101722729) endothelin 3
- dog(403406) endothelin 3
- chicken(768509) endothelin 3
- Horse(100034064) endothelin 3
- sheep(101114458) endothelin 3
- domestic guinea pig(100733839) endothelin 3
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