CYP1A2
cytochrome P450, family 1, subfamily A, polypeptide 2
Sinónimos:
CP12, P3-450, P450(PA)
Especie:
Human CYP1A2 (1544), Mouse Cyp1a2 (13077), Rat Cyp1a2 (24297), domestic guinea pig Cyp1a2 (100135513), domestic cat CYP1A2 (554345), chicken CYP1A2 (414856), cow CYP1A2 (503552), dog CYP1A2 (494010)
ID UniProtKB:
ID del gen:
- Human(1544) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
- Mouse(13077) cytochrome P450, family 1, subfamily a, polypeptide 2
- Rat(24297) cytochrome P450, family 1, subfamily a, polypeptide 2
- domestic guinea pig(100135513) cytochrome P450, family 1, subfamily a, polypeptide 2
- domestic cat(554345) cytochrome P450 1A2
- chicken(414856) cytochrome P450, family 1, subfamily A, polypeptide 2
- cow(503552) cytochrome P450, family 1, subfamily A, polypeptide 2
- dog(494010) cytochrome P450, family 1, subfamily A, polypeptide 2
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