CDK6
cyclin-dependent kinase 6
Sinónimos:
PLSTIRE
Especie:
Human CDK6 (1021), Mouse Cdk6 (12571), Rat Cdk6 (114483), domestic guinea pig Cdk6 (100732773), naked mole-rat Cdk6 (101719908), Domestic Rabbit CDK6 (100009040), sheep CDK6 (100144761), Horse CDK6 (100061625), cow CDK6 (511754), dog CDK6 (609920) ...Más
ID UniProtKB:
ID del gen:
- Human(1021) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
- Mouse(12571) cyclin-dependent kinase 6
- Rat(114483) cyclin-dependent kinase 6
- domestic guinea pig(100732773) cyclin-dependent kinase 6
- naked mole-rat(101719908) cyclin-dependent kinase 6
- Domestic Rabbit(100009040) cyclin-dependent kinase 6
- sheep(100144761) cyclin-dependent kinase 6
- Horse(100061625) cyclin-dependent kinase 6
- cow(511754) cyclin-dependent kinase 6
- dog(609920) cyclin-dependent kinase 6
- domestic cat(100037415) cyclin-dependent kinase 6
- chicken(420558) cyclin-dependent kinase 6
- Zebrafish(100034507) cyclin-dependent kinase 6
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-CDK6 Antibody, clone 2J3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-CDK6 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CDK6 (Ab-13) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-CDK6 (Ab-24) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
western blot
Anti-CDK6 antibody produced in rabbit, ,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Referencia del producto
Descripción
Especie
Proteins
Referencia del producto
Descripción
Especie
CDK6/CyclinD1, active, His/GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human