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Merck

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Sinónimos:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Especie:
ID UniProtKB:
ID del gen:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

Custom & Knockdown Gene Products

Small Molecule - Allosteric Modulator

Número de producto
Descripción
Especie
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Especie
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Gabapentin, solid,
Especie
human, rat

Small Molecule - Antagonist

Número de producto
Descripción
Especie
Nimodipine, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Nimodipine, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Especie
human

Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-CACNA1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Monoclonal Anti-CACNA1D antibody produced in mouse, clone S48A-9, 1 mg/mL, purified immunoglobulin,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunoprecipitation (IP)

western blot
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reactividad de especies
mouse, rat
Aplicación
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Número de producto
Descripción
Especie
Margatoxin, ,
Especie
mouse, rat, human
Amlodipine besylate, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Amlodipine besylate, ≥98% (HPLC),
Especie
human
Amlodipine besylate, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Amlodipine besylate, European Pharmacopoeia (EP) Reference Standard,
Especie
human

esiRNA

Número de producto
Descripción
Especie
MISSION® esiRNA, targeting human CACNA1D,
Especie
human