ATR
ataxia telangiectasia and Rad3 related
Sinónimos:
FCTCS, FRP1, MEC1, SCKL, SCKL1
Especie:
Human ATR (545), Mouse Atr (245000), Rat Atr (685055), Thale Cress ATR (834082), Zebrafish atr (567770), chicken ATR (424777), dog ATR (477101), domestic cat ATR (101088023), Horse ATR (100062529), cow ATR (504869) ...Más
ID UniProtKB:
ID del gen:
- Human(545) Summary: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
- Mouse(245000) ataxia telangiectasia and Rad3 related
- Rat(685055) ataxia telangiectasia and Rad3 related
- Thale Cress(834082) serine/threonine-protein kinase ATR
- Zebrafish(567770) ataxia telangiectasia and Rad3 related
- chicken(424777) ataxia telangiectasia and Rad3 related
- dog(477101) ataxia telangiectasia and Rad3 related
- domestic cat(101088023) ataxia telangiectasia and Rad3 related
- Horse(100062529) ataxia telangiectasia and Rad3 related
- cow(504869) ataxia telangiectasia and Rad3 related
- sheep(101106566) ataxia telangiectasia and Rad3 related
- Domestic Rabbit(100359062) ataxia telangiectasia and Rad3 related
- domestic guinea pig(100732693) ataxia telangiectasia and Rad3 related
- naked mole-rat(101701996) ataxia telangiectasia and Rad3 related
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Phospho-ATR-S428 antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot
Anti-ATR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-ATR (Ab-428) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunohistochemistry
Rabbit anti-ATR Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
western blot