ASXL1
additional sex combs like 1 (Drosophila)
Sinónimos:
BOPS, MDS
Especie:
Human ASXL1 (171023), Mouse Asxl1 (228790), Rat Asxl1 (311553), cow ASXL1 (522091), sheep ASXL1 (101113692), Horse ASXL1 (100068681), naked mole-rat Asxl1 (101705975), domestic guinea pig Asxl1 (100732603), dog ASXL1 (100688017), Zebrafish asxl1 (403066) ...Más
ID UniProtKB:
ID del gen:
- Human(171023) Summary: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
- Mouse(228790) additional sex combs like 1
- Rat(311553) additional sex combs like 1
- cow(522091) additional sex combs like 1 (Drosophila)
- sheep(101113692) additional sex combs like 1 (Drosophila)
- Horse(100068681) additional sex combs like 1 (Drosophila)
- naked mole-rat(101705975) additional sex combs like 1 (Drosophila)
- domestic guinea pig(100732603) additional sex combs like 1 (Drosophila)
- dog(100688017) additional sex combs like 1 (Drosophila)
- Zebrafish(403066) additional sex combs like 1 (Drosophila)
- domestic cat(101100957) additional sex combs like 1 (Drosophila)
- chicken(428158) additional sex combs like 1 (Drosophila)
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