ALDH2
aldehyde dehydrogenase 2 family (mitochondrial)
Sinónimos:
ALDH-E2, ALDHI, ALDM
Especie:
Human ALDH2 (217), Mouse Aldh2 (11669), Rat Aldh2 (29539), naked mole-rat Aldh2 (101706449), sheep ALDH2 (101116511), domestic guinea pig Aldh2 (100730314), dog ALDH2 (610941), domestic cat ALDH2 (101082267), cow ALDH2 (508629), Domestic Rabbit ALDH2 (100338523)
ID UniProtKB:
ID del gen:
- Human(217) Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
- Mouse(11669) aldehyde dehydrogenase 2, mitochondrial
- Rat(29539) aldehyde dehydrogenase 2 family (mitochondrial)
- naked mole-rat(101706449) aldehyde dehydrogenase 2 family (mitochondrial)
- sheep(101116511) aldehyde dehydrogenase 2 family (mitochondrial)
- domestic guinea pig(100730314) aldehyde dehydrogenase 2 family (mitochondrial)
- dog(610941) aldehyde dehydrogenase 2 family (mitochondrial)
- domestic cat(101082267) aldehyde dehydrogenase 2 family (mitochondrial)
- cow(508629) aldehyde dehydrogenase 2 family (mitochondrial)
- Domestic Rabbit(100338523) aldehyde dehydrogenase 2 family (mitochondrial)
- chicken(416880) aldehyde dehydrogenase 2 family (mitochondrial)
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Antibodies
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Aplicación
Anti-ALDH2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-ALDH2 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ALDH2 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Small Molecule - Inhibitor
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Proteins
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