- Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.
Long-acting injectable atovaquone nanomedicines for malaria prophylaxis.
Nature communications (2018-01-24)
Rahul P Bakshi, Lee M Tatham, Alison C Savage, Abhai K Tripathi, Godfree Mlambo, Matthew M Ippolito, Elizabeth Nenortas, Steve P Rannard, Andrew Owen, Theresa A Shapiro
PMID29358624
ABSTRACT
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles that confers long-lived prophylaxis against Plasmodium berghei ANKA malaria in C57BL/6 mice. Protection is obtained at plasma concentrations above 200 ng ml
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Poloxamer 188 solution, 10%, sterile-filtered, BioReagent, suitable for insect cell culture