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Surface charge switching nanoparticles for magnetic resonance imaging.

Surface charge switching nanoparticles for magnetic resonance imaging.

International journal of pharmaceutics (2014-05-27)

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

ABSTRACT

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

MATERIALS

Product Number

Brand

Product Description

Supelco

N,N-Dimethylformamide, analytical standard

Supelco

Diethyl ether, analytical standard

Sigma-Aldrich

Acetic acid, for luminescence, BioUltra, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, for amino acid analysis, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, BioUltra, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, for protein sequence analysis, ampule, ≥99.5% (GC)

Sigma-Aldrich

N,N-Dimethylformamide, ACS reagent, ≥99.8%

Sigma-Aldrich

Bis(trichloromethyl) carbonate, purum, ≥99.0% (AT)

Sigma-Aldrich

Acetic acid, ≥99.5%, FCC, FG

Sigma-Aldrich

N,N-Dimethylformamide, anhydrous, 99.8%

Sigma-Aldrich

Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

Dodecylamine, 98%

Sigma-Aldrich

Lauric acid, natural, ≥98%, FCC, FG

Sigma-Aldrich

Lauric acid, ≥98%, FCC, FG

Sigma-Aldrich

Dodecylamine, ≥99%

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

Triethylamine, ≥99%

Sigma-Aldrich

Acetic acid-¹²C₂, 99.9 atom % ¹²C

Sigma-Aldrich

N,N-Dimethylformamide, suitable for HPLC, ≥99.9%

Sigma-Aldrich

Dodecylamine, puriss., ≥99.5% (GC)

Sigma-Aldrich

N,N-Dimethylformamide, for molecular biology, ≥99%

Supelco

Acetic acid, analytical standard

Sigma-Aldrich

Diethyl ether, puriss. p.a., ACS reagent, ≥99.8% (GC)

Sigma-Aldrich

Diethyl ether, suitable for HPLC, ≥99.9%, inhibitor-free

Sigma-Aldrich

Acetic acid, natural, ≥99.5%, FG

Sigma-Aldrich

N,N-Dimethylformamide, suitable for HPLC, ≥99.9%

Lauric acid, European Pharmacopoeia (EP) Reference Standard

Supelco

Triethylamine, analytical standard