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Zinc and myocardial ischemia/reperfusion injury.

Zinc and myocardial ischemia/reperfusion injury.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2013-08-29)

Zhelong Xu, Juan Zhou

ABSTRACT

As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Zinc, shot, <12 mm, 99.99% trace metals basis

Sigma-Aldrich

Zinc, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular

Sigma-Aldrich

Zinc, shot, 5 mm, 99.999% trace metals basis

Sigma-Aldrich

Zinc, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

Zinc, sticks, diam. 7-10 mm, 99.97% trace metals basis

Sigma-Aldrich

Zinc, foil, thickness 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

Zinc, pieces, 2-14 mesh, 99.9% trace metals basis

Sigma-Aldrich

Zinc, nanopowder, 40-60 nm avg. part. size, ≥99% trace metals basis

Sigma-Aldrich

Zinc, dust, <10 μm, ≥98%

Sigma-Aldrich

Zinc preparation, 5 g/dL Zn⁺² in THF, highly reactive Rieke^®metal

Zinc, foil, 6mm disks, thickness 0.125mm, as rolled, 99.99+%

Zinc, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

Zinc, foil, 8mm disks, thickness 0.125mm, as rolled, 99.95+%

Zinc, foil, 8mm disks, thickness 0.15mm, as rolled, 99.95+%

Zinc, foil, 8mm disks, thickness 1.0mm, as rolled, 99.99+%

Zinc, foil, 8mm disks, thickness 0.5mm, as rolled, 99.99+%

Zinc, foil, not light tested, 25x25mm, thickness 0.015mm, 99.9%

Zinc, foil, 8mm disks, thickness 0.125mm, as rolled, 99.99+%

Zinc, foil, 6mm disks, thickness 0.20mm, as rolled, 99.95+%

Zinc, foil, not light tested, 50x50mm, thickness 0.015mm, 99.9%

Zinc, foil, not light tested, 50x50mm, thickness 0.01mm, 99.9%

Zinc, wire reel, 5m, diameter 3.0mm, extruded, 99.9%

Zinc, wire reel, 50m, diameter 1.0mm, extruded, 99.9%

Zinc, wire reel, 10m, diameter 2.0mm, extruded, 99.9%

Sigma-Aldrich

Zinc, granular, 20-30 mesh, ACS reagent, ≥99.8%

Zinc, wire reel, 5m, diameter 1.0mm, extruded, 99.9%

Zinc, wire reel, 5m, diameter 2.0mm, extruded, 99.9%

Zinc, foil, 100x100mm, thickness 0.175mm, as rolled, 99.95+%

Zinc, foil, 100x100mm, thickness 6mm, as rolled, 99.99+%

Zinc, foil, 50x50mm, thickness 0.1mm, as rolled, 99.95+%