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Merck

Substrate-induced rearrangements in glutamate-transporter homologs.

Nature structural & molecular biology (2013-10-08)
Baruch I Kanner
PMID24096399
ABSTRACT

Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.

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