- Transition metal-free direct C-H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes.
Transition metal-free direct C-H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes.
Chemical communications (Cambridge, England) (2012-10-18)
Liang-Hua Zou, Jens Reball, Jakob Mottweiler, Carsten Bolm
PMID23072812
ABSTRACT
A convenient transition metal-free procedure for the direct thiolation of 1,3,4-oxadiazole C-H bonds using diaryl disulfides has been developed. Other substrates including indole, benzothiazole, N-phenylbenzimidazole, and caffeine were also thiolated in this manner, providing the corresponding products in good to excellent yields.