- Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.
Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade.
Journal of the American Chemical Society (2012-06-22)
Shaolin Zhu, David W C MacMillan
PMID22716914
ABSTRACT
An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.
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