- A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones.
A new and efficient method for the synthesis of 3,4-disubstituted pyrrolidine-2,5-diones.
Molecules (Basel, Switzerland) (2012-05-02)
Eleonora D Ilieva, Nevena I Petkova, Rositca D Nikolova
PMID22547316
ABSTRACT
A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.
MATERIALS