Skip to Content
Merck

Nicotinamide adenine dinucleotide: beyond a redox coenzyme.

Organic & biomolecular chemistry (2007-11-21)
Hening Lin
PMID18019526
ABSTRACT

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

MATERIALS
Product Number
Brand
Product Description
N6005
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate, ≥94% (HPLC)
N8129
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate, ≥97% (HPLC)
N1161
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate, ~98%, pkg of 100 mg
N0786
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 1 mg (per vial)
N6785
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 10 mg (per vial)
N7410
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 2 mg (per vial)
N9410
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 5 mg (per vial)
N8285
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial)
N7132
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide lithium salt from Saccharomyces cerevisiae, ≥95%
N6660
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 0.2 mg (per vial)
N9535
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced disodium salt, ~98%, pkg of 25-30 mg (per vial)
N8410
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, pkg of 20 mg (per vial)
N4505
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, reduced dipotassium salt
N8535
Sigma-Aldrich
β-Nicotinamide adenine dinucleotide, pkg of 50 mg (per vial)