SRP5107
p19INK4D, GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
CDKN2D, INK4D, p19, p19-INK4D
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
recombinant
expressed in E. coli
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~44 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CDKN2D(1032)
General description
p19INK4D protein is associated with CDK6 in several hematopoietic cell lines. It has been demonstrated that p19INK4D expression enhances cell survival under genotoxic conditions. By using p19INK4D-overexpressing cells, it has been demonstrated that p19INK4D expression correlates with the cellular resistance to UV treatment with increased DNA repair activity against UV-induced lesions. p19INK4D regulates protein network that integrate DNA repair, apoptosis and checkpoint mechanisms in order to maintain the genomic integrity.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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K L Guan et al.
Molecular biology of the cell, 7(1), 57-70 (1996-01-01)
Cyclin-dependent kinases 4 and 6 are complexed with many small cellular proteins in vivo. We have isolated cDNA sequences, INK4d, encoding a 19-kDa protein that is associated with CDK6 in several hematopoietic cell lines. p19 shares equal similarity and a
Julieta M Ceruti et al.
Oncogene, 24(25), 4065-4080 (2005-03-08)
The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of
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