Skip to Content
Merck
All Photos(1)

Documents

565610

Sigma-Aldrich

SC-560

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC₅₀ = 9 nM).

Synonym(s):

SC-560, 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H12F3IN2O
CAS Number:
188817-13-2
Molecular Weight:
456.20
MDL number:
MFCD02179214
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3

InChI key

PQUGCKBLVKJMNT-UHFFFAOYSA-N

General description

A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM). Inhibits COX-2 only at higher concentrations (IC50 = 6.3 µM).
A cell-permeable, highly potent and selective inhibitor of cyclooxygenase-1 (COX-1; IC50 = 9 nM). Inhibits cyclooxygenase-2 (COX-2) only at higher concentrations (IC50 = 6.3 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no
Target IC50: 9 nM against COX-1

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524.
Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Oluwatobiloba Osikoya et al.
Pharmacological research, 171, 105788-105788 (2021-07-27)
Uterine perivascular adipose tissue (PVAT) contributes to uterine blood flow regulation in pregnancy, at least in part, due to its effects on uterine artery reactivity. We tested the hypothesis that uterine PVAT modulates the balance between the contribution of nitric
Ichitaro Abe et al.
Developmental cell, 57(23), 2623-2637 (2022-12-07)
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-derived linoleic acid triggers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service