F5132
Factor II from human plasma
lyophilized powder, 5-20 units/mg protein
Synonym(s):
Prothrombin
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About This Item
form
lyophilized powder
specific activity
5-20 units/mg protein
UniProt accession no.
foreign activity
factor X <0.01% of base activity
thrombin, none detected
storage temp.
−20°C
Gene Information
human ... F2(2147)
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Biochem/physiol Actions
Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.
Unit Definition
One unit is the amount contained in one mL of normal human plasma.
Reconstitution
When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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György Miklós Buzás
Orvosi hetilap, 154(21), 810-819 (2013-05-23)
Tumor markers are gene products which signal the occurrence of tumors in different organs as well as their response to surgery and chemotherapy. The discovery of tumor markers occurred after the demonstration of tumor-specific transplantation antigens in chemically or virally
Ayako Tomono et al.
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(5), 852-860 (2013-05-08)
A 78-year-old man was admitted for workup for a liver tumor. Both serum AFP and PIVKA-II levels were high (2260ng/ml and 806mAU/ml, respectively). Contrast-enhanced CT scan and MRI using Gd-EOB-DTPA demonstrated a liver tumor in segment 6 resembling the imaging
Masahiko Tameda et al.
Cancer science, 104(6), 725-731 (2013-03-14)
Serum tumor markers, including α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), are currently used in the diagnosis of hepatocellular carcinoma (HCC). There is, however, an aberrant increase in serum DCP in patients with obstructive jaundice, vitamin K deficiency or who are
Yuichiro Yanagida et al.
Surgery, 154(1), 48-57 (2013-05-21)
We tested the hypotheses that an increase in systemic thrombin activity occurs in both disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype and in acute coagulopathy of trauma shock (ACoTS), and that the patients diagnosed as having ACoTS overlap or
Maria M Aleman et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1829-1836 (2013-06-01)
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of
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