VAV1
vav 1 guanine nucleotide exchange factor
Synonyms:
VAV
Species:
Human VAV1 (7409), Mouse Vav1 (22324), Rat Vav1 (25156), cow VAV1 (617345), domestic guinea pig Vav1 (100713221), naked mole-rat Vav1 (101700388), dog VAV1 (485016), domestic cat VAV1 (101097212), sheep VAV1 (101107354)
UniProtKB ID:
Gene ID:
- Human(7409) Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
- Mouse(22324) vav 1 oncogene
- Rat(25156) vav 1 guanine nucleotide exchange factor
- cow(617345) vav 1 guanine nucleotide exchange factor
- domestic guinea pig(100713221) vav 1 guanine nucleotide exchange factor
- naked mole-rat(101700388) vav 1 guanine nucleotide exchange factor
- dog(485016) vav 1 guanine nucleotide exchange factor
- domestic cat(101097212) vav 1 guanine nucleotide exchange factor
- sheep(101107354) vav 1 guanine nucleotide exchange factor
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-VAV1 (pTyr174) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
western blot
Anti-VAV1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-VAV1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-VAV1 (Ab-174) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
western blot