PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
Synonyms:
PP2C-ALPHA, PP2CA, PP2Calpha
Species:
Human PPM1A (5494), Mouse Ppm1a (19042), Rat Ppm1a (24666), Domestic Rabbit PPM1A (100009431), domestic cat PPM1A (101101571), naked mole-rat Ppm1a (101720711), sheep PPM1A (101103650), domestic guinea pig Ppm1a (100734826), cow PPM1A (281994), dog PPM1A (480344)
UniProtKB ID:
Gene ID:
- Human(5494) Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(19042) protein phosphatase 1A, magnesium dependent, alpha isoform
- Rat(24666) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- Domestic Rabbit(100009431) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- domestic cat(101101571) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- naked mole-rat(101720711) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- sheep(101103650) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- domestic guinea pig(100734826) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- cow(281994) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- dog(480344) protein phosphatase, Mg2+/Mn2+ dependent, 1A
- chicken(423525) protein phosphatase, Mg2+/Mn2+ dependent, 1A
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PPM1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot