PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Synonyms:
F6PK, HL2K, PFRX
Species:
Human PFKFB1 (5207), Mouse Pfkfb1 (18639), Rat Pfkfb1 (24638), chicken PFKFB1 (770873), Zebrafish pfkfb1 (327453), domestic cat PFKFB1 (101094910), dog PFKFB1 (491903), Domestic Rabbit PFKFB1 (100345023), sheep PFKFB1 (101116538), cow PFKFB1 (282304) ...More
UniProtKB ID:
Gene ID:
- Human(5207) Summary: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
- Mouse(18639) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Rat(24638) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- chicken(770873) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Zebrafish(327453) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- domestic cat(101094910) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- dog(491903) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Domestic Rabbit(100345023) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- sheep(101116538) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- cow(282304) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Horse(100062514) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- naked mole-rat(101701867) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- domestic guinea pig(100722672) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.