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Merck

NDUFS1

NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

Synonyms:
CI-75Kd, CI-75k, PRO1304
Species:
UniProtKB ID:
Gene ID:
  • Human(4719) Summary: The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
  • Mouse(227197) NADH dehydrogenase (ubiquinone) Fe-S protein 1
  • Rat(301458) NADH dehydrogenase (ubiquinone) Fe-S protein 1
  • Zebrafish(493605) NADH dehydrogenase (ubiquinone) Fe-S protein 1
  • chicken(424102) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • domestic guinea pig(100726311) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • naked mole-rat(101698993) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • cow(288380) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • sheep(101115434) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • Goat(100861376) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • domestic cat(101100747) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • dog(478880) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
  • Horse(100066330) NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-NDUFS1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Metformin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
1,1-Dimethylbiguanide hydrochloride, 97%,
Species
human
Metformin hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Metformin hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Metformin hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human NDUFS1,
Species
human
MISSION® esiRNA, targeting mouse Ndufs1,
Species
mouse