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Merck

KCNJ11

potassium inwardly-rectifying channel, subfamily J, member 11

Synonyms:
BIR, HHF2, IKATP, KIR6.2, PHHI, TNDM3
Species:
UniProtKB ID:
Gene ID:
  • Human(3767) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(16514) potassium inwardly rectifying channel, subfamily J, member 11
  • Rat(83535) potassium inwardly rectifying channel, subfamily J, member 11
  • domestic cat(101097019) potassium inwardly-rectifying channel, subfamily J, member 11
  • sheep(101114135) potassium inwardly-rectifying channel, subfamily J, member 11
  • Horse(100056520) potassium inwardly-rectifying channel, subfamily J, member 11
  • Zebrafish(664687) potassium inwardly-rectifying channel, subfamily J, member 11
  • Domestic Rabbit(100008648) potassium inwardly-rectifying channel, subfamily J, member 11
  • naked mole-rat(101705172) potassium inwardly-rectifying channel, subfamily J, member 11
  • dog(485401) potassium inwardly-rectifying channel, subfamily J, member 11
  • chicken(428846) potassium inwardly-rectifying channel, subfamily J, member 11
  • cow(532060) potassium inwardly-rectifying channel, subfamily J, member 11
  • domestic guinea pig(100135564) potassium inwardly rectifying channel, subfamily J, member 11

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Small Molecule - Antagonist

Product Number
Description
Species
Glyburide, meets USP testing specifications,
Species
rat, human
Glybenclamide, ≥99% (HPLC),
Species
rat, human
Chlorpropamide, analytical standard, ≥97%,
Species
human, mouse
Tolbutamide, analytical standard,
Species
human, mouse
Diazoxide, ,
Species
rat, mouse, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KIR6.2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-KCNJ11 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-KIR6.2 (PHOSPHO-THR224), affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunofluorescence
western blot

Small Molecule - Blocker

Product Number
Description
Species
Glimepiride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Glimepiride, British Pharmacopoeia (BP) Reference Standard,
Species
human
Glipizide, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Repaglinide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Glipizide, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Opener

Product Number
Description
Species
Diazoxide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Diazoxide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Diazoxide, ,
Species
rat, mouse, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNJ11,
Species
human