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Merck

HTR2B

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Synonyms:
5-HT(2B), 5-HT2B
Species:
Human HTR2B (3357), Mouse Htr2b (15559), Rat Htr2b (29581), chicken HTR2B (395581), Zebrafish htr2b (751784), dog HTR2B (403881), cow HTR2B (407135), Horse HTR2B (100057052), domestic cat HTR2B (101095762), Domestic Rabbit HTR2B (100343392) ...More
UniProtKB ID:
P41595, B2R9D5, Q53TI1, Q62221, Q6P523
Gene ID:
  • Human(3357) Summary: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
  • Mouse(15559) 5-hydroxytryptamine (serotonin) receptor 2B
  • Rat(29581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • chicken(395581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Zebrafish(751784) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • dog(403881) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • cow(407135) 5-hydroxytryptamine (serotonin) receptor 2B
  • Horse(100057052) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic cat(101095762) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Domestic Rabbit(100343392) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • sheep(101106827) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • naked mole-rat(101699201) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic guinea pig(100135546) 5-hydroxytryptamine (serotonin) receptor 2B

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Small Molecule - Agonist

Product Number
Description
Species
B175
BW 723C86, ≥98% (HPLC),
Species
human
1430000
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Y0000777
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Y0000776
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Species
human
M110
α-Methylserotonin maleate salt, ≥98% (HPLC),
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
D9190
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
1430000
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Species
human
Y0000777
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Y0000776
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Species
human
S006
Ketanserin (+)-tartrate salt, ≥97%, solid,
Species
human
O111
Octoclothepin maleate salt, solid,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
SAB4501475
Anti-5-HT-2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
HPA012867
Anti-HTR2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB4501476
Anti-HTR2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
AMAB91972
Monoclonal Anti-Htr2B Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14576, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
western blot
HPA063658
Anti-HTR2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Blocker

Product Number
Description
Species
M2525
Mianserin hydrochloride, ,
Species
human
Z101
Zimelidine dihydrochloride, solid,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
F1553
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
F1678
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human
F2802
Fluvoxamine maleate, solid,
Species
human
R0875
Reserpine, ,
Species
human
F132
Fluoxetine hydrochloride, solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
M8046
Mifepristone, ≥98%,
Species
human, mouse, rat

Small Molecule - Precursor

Product Number
Description
Species
H9772
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
EHU052881
MISSION® esiRNA, targeting human HTR2B,
Species
human