HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
Synonyms:
C10orf65, DHDPS2, DHDPSL, HP3, NPL2
Species:
Human HOGA1 (112817), Mouse Hoga1 (67432), Rat Hoga1 (293949), dog HOGA1 (608755), Horse HOGA1 (100070689), domestic guinea pig Hoga1 (100720763), cow HOGA1 (506001), sheep HOGA1 (101114573), naked mole-rat Hoga1 (101700602), Zebrafish hoga1 (405806)
UniProtKB ID:
Gene ID:
- Human(112817) Summary: The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
- Mouse(67432) 4-hydroxy-2-oxoglutarate aldolase 1
- Rat(293949) 4-hydroxy-2-oxoglutarate aldolase 1
- dog(608755) 4-hydroxy-2-oxoglutarate aldolase 1
- Horse(100070689) 4-hydroxy-2-oxoglutarate aldolase 1
- domestic guinea pig(100720763) 4-hydroxy-2-oxoglutarate aldolase 1
- cow(506001) 4-hydroxy-2-oxoglutarate aldolase 1
- sheep(101114573) 4-hydroxy-2-oxoglutarate aldolase 1
- naked mole-rat(101700602) 4-hydroxy-2-oxoglutarate aldolase 1
- Zebrafish(405806) 4-hydroxy-2-oxoglutarate aldolase 1
- domestic cat(101101417) 4-hydroxy-2-oxoglutarate aldolase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HOGA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Proteins
Product Number
Description
Species
PrEST Antigen HOGA1, Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution,
Species
human
esiRNA
Product Number
Description
Species