GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
Synonyms:
CAT-2, CAT2
Species:
Human GIT2 (9815), Mouse Git2 (26431), Rat Git2 (304546), domestic cat GIT2 (101093054), Horse GIT2 (100066470), cow GIT2 (516048), dog GIT2 (477520), domestic guinea pig Git2 (100727065), chicken GIT2 (374035), naked mole-rat Git2 (101702496) ...More
UniProtKB ID:
Gene ID:
- Human(9815) Summary: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
- Mouse(26431) G protein-coupled receptor kinase-interactor 2
- Rat(304546) G protein-coupled receptor kinase interacting ArfGAP 2
- domestic cat(101093054) G protein-coupled receptor kinase interacting ArfGAP 2
- Horse(100066470) G protein-coupled receptor kinase interacting ArfGAP 2
- cow(516048) G protein-coupled receptor kinase interacting ArfGAP 2
- dog(477520) G protein-coupled receptor kinase interacting ArfGAP 2
- domestic guinea pig(100727065) G protein-coupled receptor kinase interacting ArfGAP 2
- chicken(374035) G protein-coupled receptor kinase interactor 2
- naked mole-rat(101702496) G protein-coupled receptor kinase interacting ArfGAP 2
- sheep(101121803) G protein-coupled receptor kinase interacting ArfGAP 2
- Domestic Rabbit(100348106) G protein-coupled receptor kinase interacting ArfGAP 2
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