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Merck

CCL5

chemokine (C-C motif) ligand 5

Synonyms:
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Species:
Human CCL5 (6352), Mouse Ccl5 (20304), Rat Ccl5 (81780), sheep CCL5 (101115553), domestic guinea pig Ccl5 (100135495), naked mole-rat Ccl5 (101712384), chicken CCL5 (417465), cow CCL5 (327712), Horse CCL5 (100033925), domestic cat CCL5 (493689)
UniProtKB ID:
P13501, O43646, Q0QVW8, Q4ZGJ1, Q9NYA2, Q9UBG2, Q9UC99
Gene ID:
  • Human(6352) Summary: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of two N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
  • Mouse(20304) chemokine (C-C motif) ligand 5
  • Rat(81780) chemokine (C-C motif) ligand 5
  • sheep(101115553) chemokine (C-C motif) ligand 5
  • domestic guinea pig(100135495) chemokine (C-C motif) ligand 5
  • naked mole-rat(101712384) chemokine (C-C motif) ligand 5
  • chicken(417465) chemokine (C-C motif) ligand 5
  • cow(327712) chemokine (C-C motif) ligand 5
  • Horse(100033925) chemokine (C-C motif) ligand 5
  • domestic cat(493689) chemokine (C-C motif) ligand 5
  • dog(403522) chemokine (C-C motif) ligand 5

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ELISA

Product Number
Description
Species
RAB0527
Feline CCL5 / C-C Motif Chemokine 5 ELISA Kit, for serum, plasma and cell culture supernatants,
Species
domestic cat
RAB0077
Mouse RANTES / CCL5 ELISA Kit, for serum, plasma and cell culture supernatant,
Species
mouse
RAB0076
Human RANTES / CCL5 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
RAB1827
Rhesus Macaque RANTES ELISA, for serum, plasma and cell culture supernatants,
Species

Antibodies

Product Number
Description
Species Reactivity
Application
R125
Anti-RANTES antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
immunohistochemistry
neutralization
western blot
R9400
Monoclonal Anti-RANTES antibody produced in rat, clone 53405.111, purified immunoglobulin, lyophilized powder,
Species Reactivity
mouse
Application
immunocytochemistry
neutralization

Proteins

Product Number
Description
Species
R6267
RANTES human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
Species
human
SRP3269
RANTES human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC),
Species
human

esiRNA

Product Number
Description
Species
EHU120731
MISSION® esiRNA, targeting human CCL5,
Species
human