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Merck

CACNA2D4

calcium channel, voltage-dependent, alpha 2/delta subunit 4

Synonyms:
RCD4
Species:
UniProtKB ID:
Gene ID:
  • Human(93589) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Mouse(319734) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • Rat(312668) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • chicken(100858946) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • domestic guinea pig(100716046) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • Horse(100630648) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • domestic cat(101095834) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • dog(477733) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • sheep(101116306) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • naked mole-rat(101705589) calcium channel, voltage-dependent, alpha 2/delta subunit 4
  • cow(784075) calcium channel, voltage-dependent, alpha 2/delta subunit 4

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CACNA2D4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry

Small Molecule - Blocker

Product Number
Description
Species
Bepridil hydrochloride, powder,
Species
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA2D4,
Species
human