ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Synonyms:
ATP6C, ATP6L, ATPL, VATL, VPPC, Vma3
Species:
Human ATP6V0C (527), Mouse Atp6v0c (11984), Rat Atp6v0c (170667), dog ATP6V0C (479877), cow ATP6V0C (550622), domestic guinea pig Atp6v0c (100735418), sheep ATP6V0C (443003), naked mole-rat Atp6v0c (101709243), domestic cat ATP6V0C (101101434), chicken ATP6V0C (416753)
UniProtKB ID:
Gene ID:
- Human(527) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
- Mouse(11984) ATPase, H+ transporting, lysosomal V0 subunit C
- Rat(170667) ATPase, H+ transporting, lysosomal V0 subunit C
- dog(479877) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- cow(550622) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- domestic guinea pig(100735418) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- sheep(443003) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- naked mole-rat(101709243) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- domestic cat(101101434) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
- chicken(416753) ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
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