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Merck

ATP6V0A1

ATPase, H+ transporting, lysosomal V0 subunit a1

Synonyms:
ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1
Species:
UniProtKB ID:
Gene ID:
  • Human(535) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11975) ATPase, H+ transporting, lysosomal V0 subunit A1
  • Rat(29757) ATPase, H+ transporting, lysosomal V0 subunit A1
  • Horse(100052802) ATPase, H+ transporting, lysosomal V0 subunit a1
  • domestic guinea pig(100717816) ATPase, H+ transporting, lysosomal V0 subunit a1
  • cow(286768) ATPase, H+ transporting, lysosomal V0 subunit a1
  • Zebrafish(100332691) ATPase, H+ transporting, lysosomal V0 subunit a1
  • naked mole-rat(101718747) ATPase, H+ transporting, lysosomal V0 subunit a1
  • domestic cat(101096367) ATPase, H+ transporting, lysosomal V0 subunit a1
  • sheep(101123476) ATPase, H+ transporting, lysosomal V0 subunit a1
  • dog(607705) ATPase, H+ transporting, lysosomal V0 subunit a1
  • chicken(395474) ATPase, H+ transporting, lysosomal V0 subunit a1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-ATP6V0A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ATP6V0A1,
Species
human
MISSION® esiRNA, targeting mouse Atp6v0a1,
Species
mouse