Skip to Content
Merck

Cell biology of molybdenum in plants and humans.

Biochimica et biophysica acta (2012-03-01)
Ralf R Mendel, Tobias Kruse
ABSTRACT

The transition element molybdenum (Mo) needs to be complexed by a special cofactor in order to gain catalytic activity. With the exception of bacterial Mo-nitrogenase, where Mo is a constituent of the FeMo-cofactor, Mo is bound to a pterin, thus forming the molybdenum cofactor Moco, which in different variants is the active compound at the catalytic site of all other Mo-containing enzymes. In eukaryotes, the most prominent Mo-enzymes are nitrate reductase, sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase, and the mitochondrial amidoxime reductase. The biosynthesis of Moco involves the complex interaction of six proteins and is a process of four steps, which also requires iron, ATP and copper. After its synthesis, Moco is distributed to the apoproteins of Mo-enzymes by Moco-carrier/binding proteins. A deficiency in the biosynthesis of Moco has lethal consequences for the respective organisms. In humans, Moco deficiency is a severe inherited inborn error in metabolism resulting in severe neurodegeneration in newborns and causing early childhood death. This article is part of a Special Issue entitled: Cell Biology of Metals.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Molybdenum, wire, diam. 1.0 mm, 99.95% trace metals basis
Molybdenum, wire, straight, 1000mm, diameter 1.0mm, 99.95%
Molybdenum, foil, light tested, 25x25mm, thickness 0.007mm, 99.9%
Molybdenum, foil, not light tested, 100x100mm, thickness 0.009mm, 99.9%
Molybdenum, foil, 50mm disks, thickness 0.20mm, annealed, 99.9%
Molybdenum, foil, 6mm disks, thickness 0.125mm, annealed, 99.9%
Molybdenum, foil, 50mm disks, thickness 0.15mm, annealed, 99.9%
Molybdenum, foil, 50mm disks, thickness 0.5mm, annealed, 99.9%
Molybdenum, foil, 6mm disks, thickness 0.015mm, as rolled, 99.9%
Molybdenum, foil, 6mm disks, thickness 0.01mm, 99.9%
Molybdenum, foil, 50mm disks, thickness 0.75mm, annealed, 99.9%
Molybdenum, foil, 6mm disks, thickness 0.20mm, annealed, 99.9%
Molybdenum, foil, not light tested, 25x25mm, thickness 0.001mm, 99.9%
Molybdenum, foil, light tested, 25x25mm, thickness 0.01mm, annealed, 99.9%
Molybdenum, foil, light tested, 60x60mm, thickness 0.015mm, as rolled, 99.9%
Molybdenum, foil, light tested, 29x100mm, thickness 0.0712mm, annealed, 99.9%
Molybdenum, rod, 200mm, diameter 2.0mm, centerless ground, 99.9%
Molybdenum, foil, not light tested, 25x25mm, thickness 0.0025mm, 99.9%
Molybdenum, foil, not light tested, 100x100mm, thickness 0.0125mm, 99.9%
Molybdenum, foil, light tested, 30x30mm, thickness 0.015mm, as rolled, 99.9%
Molybdenum, foil, not light tested, 25x25mm, thickness 0.002mm, 99.9%
Molybdenum, foil, not light tested, 25x25mm, thickness 0.003mm, 99.9%
Molybdenum, foil, light tested, 50x50mm, thickness 0.007mm, 99.9%
Molybdenum, foil, light tested, 50x50mm, thickness 0.01mm, annealed, 99.9%
Molybdenum, foil, not light tested, 25x25mm, thickness 0.004mm, 99.9%
Molybdenum, foil, not light tested, 150x150mm, thickness 0.008mm, 99.9%
Molybdenum, foil, not light tested, 50x50mm, thickness 0.01mm, 99.9%
Molybdenum, mesh, 50x50mm, nominal aperture 0.44mm, wire diameter 0.07mm, 50 wires/inch, open area 67%, plain weave mesh
Molybdenum, foil, not light tested, 50x50mm, thickness 0.0025mm, 99.9%
Molybdenum, foil, not light tested, 100x100mm, thickness 0.008mm, 99.9%