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  • JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.

JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.

Journal of clinical pathology (1990-09-01)
D V Parums, J L Cordell, K Micklem, A R Heryet, K C Gatter, D Y Mason
ABSTRACT

A new monoclonal antibody, JC70, raised against a membrane preparation from a spleen affected by hairy cell leukaemia, recognises a membrane bound glycoprotein identical with that of the CD31 group of monoclonal antibodies. The antibody stains a fixation resistant epitope on endothelial cells in benign and malignant conditions in a wide variety of paraffin wax embedded tissue. JC70 stained malignant endothelial cells in 10 angiosarcomas with more consistency than monoclonal or polyclonal antibodies to factor VIII related antigen (FVIII-Rag). In four cases of Kaposi's sarcoma the antibody stained malignant endothelial cells but not spindle cells. It is concluded that antibody JC70 is of value for studying benign and malignant human vascular disorders in routinely processed tissue.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Blood Vessel Staining Kit, Reagents & materials supplied in the Blood Vessel Staining Kit are sufficient for staining 100 tissue sections & when stored at 2-8ºC is stable up to the expiration date.
Sigma-Aldrich
CD31 (JC70) Mouse Monoclonal Antibody