SnCl2-catalyzed selective atom economic imino Diels-Alder reaction: synthesis of 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolines.

SnCl2-catalyzed selective atom economic imino Diels-Alder reaction: synthesis of 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolines.

The Journal of organic chemistry (2012-01-11)

Rajendran Suresh, Shanmugam Muthusubramanian, Rajendran Senthilkumaran, Govindaswamy Manickam

ABSTRACT

The synthesis of 2-(1H-pyrrolo[2,3-b]pyridin-3-yl)quinolines by a SnCl(2)-catalyzed multicomponent reaction has been described. The reaction proceeds chemo- and regioselectively in an atom-economic way, generating a library of 24 quinoline derivatives.

MATERIALS

Product Number

Brand

Product Description

96527

Supelco

Tin(II) chloride dihydrate, suitable for AAS

474762

Sigma-Aldrich

Tin(II) chloride dihydrate, ≥99.97% trace metals basis

204722

Sigma-Aldrich