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  • An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.

An Efficient one-pot Biginelli condensation of aliphatic aldehydes catalyzed by zinc bromide under solvent-free conditions.

Preparative biochemistry & biotechnology (2007-09-13)
Yang Yu, Di Liu, Chunsheng Liu, Heng Jiang, Genxiang Luo
ABSTRACT

Zinc bromide catalyzes the three component condensation reaction of an aldehyde, urea, and beta-ketoester or beta-diketone under solvent-free conditions to afford the corresponding dihydropyrimidinones (DHPMs) with moderate to high yields in short reaction time. The present method is very effective for the Biginelli condensation of aliphatic aldehydes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Zinc bromide, 99.999% trace metals basis
Sigma-Aldrich
Zinc bromide, AnhydroBeads, −10 mesh, 99.999% trace metals basis
Sigma-Aldrich
Zinc bromide, puriss., anhydrous, ≥98%