SML1277
Geldanamycin-FITC
≥98% (HPLC), from Streptomyces hygroscopicus
Synonym(s):
Geldanamycin, fluorescein isothiocyanate labeled
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About This Item
Empirical Formula (Hill Notation):
C55H63N5O13S
Molecular Weight:
1034.18
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
biological source
Streptomyces hygroscopicus
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
yellow to yellow-orange
solubility
DMSO: soluble 5 mg/mL
antibiotic activity spectrum
neoplastics
Mode of action
enzyme | inhibits
storage temp.
−20°C
General description
Chemical structure: benzenoid
Biochem/physiol Actions
Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.
Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Dora Posfai et al.
Antimicrobial agents and chemotherapy, 62(4) (2018-01-18)
Malaria remains a global health burden partly due to Plasmodium parasite resistance to first-line therapeutics. The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an essential protein for blood-stage Plasmodium parasites, but details about its function during malaria's
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