528240
Platelet Membrane Glycoproteins, IIbIIIa, Human Platelets
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.25
Recommended Products
form
liquid
Quality Level
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
shipped in
wet ice
storage temp.
−70°C
General description
Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
Native, platelet membrane glycoprotein IIbIIIaA from human platelets. A platelet integrin that binds to fibrinogen via the recognition sequence Arg-Gly-Asp-Ser. Acts as a receptor for such adhesive ligands as fibrinogen, fibronectin and von Willebrand factor during platelet stimulation. Glycoproteins IIb and IIIa constitute the fibrinogen receptor and are required for platelet aggregation. Glycoprotein IIb consists of two disulfide-linked subunits, GPIIbα and GPIIbβ, whereas GPIIIa has only one polypeptide chain.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 100 mM NaCl, 20 mM Tris-HCl, 1 mM CaCl2, 50% glycerol, ≤0.1% sodium azide, pH 7.4.
Preparation Note
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C). Avoid freeze/thaw cycles.
Other Notes
Schwarz M., et al. 2004. J. Pharmacol. Exp. Therap.308, 1002.
Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
Wippler, J., et al. 1994. J. Biol. Chem. 269, 8754.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
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