Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

326941

Sigma-Aldrich

Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis

IRMM523C

Aluminum, IRMM^®, certified reference material, 1.0 mm wire

IRMM523B

Aluminum, IRMM^®, certified reference material, 1.0 mm foil

733369

Sigma-Aldrich

Aluminum, foil, thickness 8 μm, 99% trace metals basis

433705

Sigma-Aldrich

Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

326887

Sigma-Aldrich

Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis

11009

Sigma-Aldrich

Aluminum, powder, ≥91% (complexometric)

518573

Sigma-Aldrich

Aluminum, granular, <1 mm, 99.7% trace metals basis

266558

Sigma-Aldrich

Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis

310360

Sigma-Aldrich

Aluminum, ACS reagent, 99%, wire, wire diam. ~1.5 mm

GF48732532

Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%

GF65371327

Aluminum, wire reel, 50m, diameter 0.5mm, as drawn, 99.5%

GF41557035

Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.0+%

GF72634103

Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%

GF06197014

Aluminum, rod, 200mm, diameter 10.0mm, as drawn, 99.999%

GF16562246

Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF12154171

Aluminum, sphere, 200pcs, diameter 6.0mm, 99%

GF32029444

Aluminum, rod, 100mm, diameter 12.7mm, 99%

GF85927056

Aluminum, microleaf disks, 25mm, thinness 0.5μm, specific density 120.6μg/cm², removable support, 99.999%

GF95825403

Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF85983205

Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm², removable support, 99.999%

GF52495500

Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

GF93309037

Aluminum, tube, 200mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF47839124

Aluminum, insulated wire, 20m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%

GF54273944

Aluminum, tube, 500mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%

GF93280732

Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%

GF36586042

Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%

GF20784360

Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF86733726

Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%

GF72881297

Aluminum, microfoil, disks, 50mm, thinness 1.0μm, specific density 269.9μg/cm², permanent mylar 3.5μm support, 99.999%