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Key Documents

SCP0003

Sigma-Aldrich

Proteasome Substrate 1, fluorogenic

≥95% (HPLC), lyophilized

Synonym(s):

Z-LLL-AMC, Z-Leu-Leu-Leu-AMC

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About This Item

Empirical Formula (Hill Notation):
C36H48N4O7
Molecular Weight:
648.79
UNSPSC Code:
12352200
NACRES:
NA.32

product name

Proteasome Substrate 1, fluorogenic,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Z-Leu-Leu-Leu-AMC

Biochem/physiol Actions

Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Oriane Tasta et al.
Free radical biology & medicine, 164, 303-314 (2021-01-16)
Premature placental senescence is a hallmark of pregnancy-related disorders such as intrauterine growth restriction (IUGR) and preeclampsia (PE), two major cause of maternal and neonatal morbidity and mortality. Oxidative stress and lipid peroxidation are involved in the pathogenesis of PE
S Tsubuki et al.
Biochemical and biophysical research communications, 196(3), 1195-1201 (1993-11-15)
A tripeptide aldehyde protease inhibitor, benzyloxycarbonyl(Z)-Leu-Leu-leucinal (ZLLLa1), initiates neurite outgrowth in PC12 cells at an optimal concentration of 30nM. This result suggests the existence of a protease which regulates neurite formation in PC12 cells. We report here an attempt to

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