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62476

Sigma-Aldrich

Lithium chloride

BioUltra, for molecular biology, anhydrous, ≥99.0% (AT)

Synonym(s):

LiCl

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About This Item

Linear Formula:
LiCl
CAS Number:
7447-41-8
Molecular Weight:
42.39
EC Number:
231-212-3
MDL number:
MFCD00011078
UNSPSC Code:
12352302
PubChem Substance ID:
57651888
NACRES:
NA.26

grade

for molecular biology

Quality Level

200

product line

BioUltra

Assay

≥99.0% (AT)

form

powder or crystals

impurities

DNases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected
≤0.001% total nitrogen (N)

loss

≤1% loss on drying, 110 °C

pH

5.0-7.5 (25 °C, 1 M in H2O)

mp

605 °C (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.2 mg/kg
Ba: ≤10 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤10 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01

SMILES string

[Li+].[Cl-]

InChI

1S/ClH.Li/h1H;/q;+1/p-1

InChI key

KWGKDLIKAYFUFQ-UHFFFAOYSA-M

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Application


  • The preconditioning of lithium promotes mesenchymal stem cell-based therapy for the degenerated intervertebral disc via upregulating cellular ROS: This study explores the use of lithium chloride in enhancing the efficacy of mesenchymal stem cells for intervertebral disc regeneration. Lithium chloride′s role in modulating cellular responses and oxidative stress mechanisms presents a potential application in developing advanced IVD (In Vitro Diagnostics) products that rely on cellular technologies (Zhu et al., 2021).


Other Notes

Precipitation of RNA; Transformation of intact yeast cells treated with alkali cations

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G Cathala et al.
DNA (Mary Ann Liebert, Inc.), 2(4), 329-335 (1983-01-01)
A method for isolation of large, translationally active RNA species is presented. The procedure involves homogenization of cells or tissues in 5 M guanidine monothiocyanate followed by direct precipitation of RNA from the guanidinium by 4 M LiCl. Modifications are
D.M. Wallace
Methods in Enzymology, 152, 48-48 (1987)
C Auffray et al.
European journal of biochemistry, 107(2), 303-314 (1980-06-01)
A procedure is described for the large-scale purification of light (L) and heavy (H) chain mRNAs from plasmacytomas produced in mice. Intact RNA is selectively precipitated in high yield from frozen tumors homogenized in 3 M LiCl and 6 M
H Ito et al.
Journal of bacteriology, 153(1), 163-168 (1983-01-01)
Intact yeast cells treated with alkali cations took up plasmid DNA. Li+, Cs+, Rb+, K+, and Na+ were effective in inducing competence. Conditions for the transformation of Saccharomyces cerevisiae D13-1A with plasmid YRp7 were studied in detail with CsCl. The
Pengyi Yang et al.
Cell systems, 8(5), 427-445 (2019-05-13)
Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell states. The two states that bookend the pluripotency continuum, naive and primed, are well characterized, but our understanding of the intermediate states and transitions between them remains
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