- Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines.
Regioselective cobalt-catalyzed formation of bicyclic 3- and 4-aminopyridines.
Organic letters (2011-03-19)
Pierre Garcia, Yannick Evanno, Pascal George, Mireille Sevrin, Gino Ricci, Max Malacria, Corinne Aubert, Vincent Gandon
PMID21413688
ABSTRACT
Bimolecular cobalt-catalyzed [2 + 2 + 2] cycloadditions between yne-ynamides and nitriles afford bicyclic 3- or 4-aminopyridines in up to 100% yield. The high regioselectivity observed depends on the substitution pattern at the starting ynamide. Aminopyridines bearing TMS and Ts groups are efficiently deprotected in an orthogonal fashion.
MATERIALS