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  • Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine.

Anaphylaxis to polyvinylpyrrolidone after vaginal application of povidone-iodine.

Contact dermatitis (2003-05-21)
Atsuko Adachi, Atsushi Fukunaga, Kazuhiro Hayashi, Makoto Kunisada, Tatsuya Horikawa
ABSTRACT

A 59-year-old woman who had had several episodes of contact urticaria after hair treatment, developed anaphylaxis after vaginal application of povidone-iodine solution for disinfection. Prick tests showed wheal-and-flare responses to both povidone-iodine (0.1% aqueous) and polyvinylpyrrolidone (povidone, PVP) (0.001% aq.), but not to iodine or polyoxy-ethyrenenonylphenyl ether, both of which are also contained in povidone-iodine solution. We confirmed that basophils from her peripheral blood released considerable amounts of histamine on stimulation by PVPs. It appeared that both the shampoo and the permanent-wave solution contained polyvinylpyrrolidone N, N-dimethyl aminoethyl methacrylic acid copolymer diethyl sulphate solution and polyvinylpyrrolidone styrene-copolymer emulsion. Both these agents in the hair care products provoked an immediate skin response on prick testing. We speculate that sensitization to PVP had been established by these hair care products at a beauty parlor. She was recommended to avoid PVP-containing products and remained free from symptoms thereafter.

MATERIALS
Product Number
Brand
Product Description

Povidone, European Pharmacopoeia (EP) Reference Standard
USP
Crospovidone, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Kollidon® 25
Sigma-Aldrich
Povidone, meets USP testing specifications
USP
Povidone, United States Pharmacopeia (USP) Reference Standard
Supelco
Povidone, Pharmaceutical Secondary Standard; Certified Reference Material
Crospovidone, European Pharmacopoeia (EP) Reference Standard
Supelco
Poly(vinylpolypyrrolidone), ~110 μm particle size
Sigma-Aldrich
Polyvinylpyrrolidone, K 90
Sigma-Aldrich
Polyvinylpyrrolidone, K 30
Sigma-Aldrich
Polyvinylpyrrolidone solution, K 60, 45% in H2O
Sigma-Aldrich
Polyvinylpyrrolidone, powder, average Mw ~55,000
Sigma-Aldrich
Polyvinylpyrrolidone, powder, average Mw ~29,000
Sigma-Aldrich
Polyvinylpyrrolidone, average Mw ~1,300,000 by LS
Sigma-Aldrich
Polyvinylpyrrolidone, average mol wt 10,000
Sigma-Aldrich
Polyvinylpyrrolidone, suitable for plant cell culture, average mol wt 10,000
Sigma-Aldrich
Polyvinylpyrrolidone, mol wt (number average molecular weight Mn 360kDa)
Sigma-Aldrich
Polyvinylpyrrolidone, powder, BioXtra, suitable for mouse embryo cell culture
Sigma-Aldrich
Polyvinylpyrrolidone, average mol wt 40,000
Sigma-Aldrich
Polyvinylpyrrolidone, for molecular biology, nucleic acid hybridization tested, mol wt 360,000
Sigma-Aldrich
Polyvinylpyrrolidone, K 25, tested according to Ph. Eur.