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  • Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.

Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.

Acta clinica Belgica (2014-04-15)
S Izdes, N D Altintas, C Soykut
ABSTRACT

Verapamil intoxication is a life-threatening condition that often presents with severe hemodynamic instability and requires vasopressor support. There are also documented case reports of the development of non-cardiogenic pulmonary oedema after verapamil overdose. However, the exact mechanisms responsible for pulmonary oedema remain unclear. Here, we describe a 36-year-old woman who was admitted to the intensive care unit after ingesting high-dose verapamil and subsequently developed acute respiratory distress syndrome soon after hemodynamic stabilization. Possible mechanisms are presented after taking into account findings in the current literature. Acute respiratory distress syndrome should be considered early during the evaluation of patients with verapamil intoxication.

MATERIALS
Product Number
Brand
Product Description

Supelco
(±)-Verapamil hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Verapamil hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
(±)-Verapamil hydrochloride, ≥99% (titration), powder
USP
Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard
Verapamil hydrochloride, European Pharmacopoeia (EP) Reference Standard