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  • A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

Psychiatry research (2013-01-02)
Jennifer C Naylor, Trygve R Dolber, Jennifer L Strauss, Jason D Kilts, Timothy J Strauman, Daniel W Bradford, Steven T Szabo, Nagy A Youssef, Kathryn M Connor, Jonathan R T Davidson, Christine E Marx
ABSTRACT

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.

MATERIALS
Product Number
Brand
Product Description

Supelco
Paroxetine maleate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Paroxetine for system suitability, European Pharmacopoeia (EP) Reference Standard
Paroxetine hydrochloride hemihydrate, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Paroxetine hydrochloride hemihydrate, ≥98% (HPLC), powder
Sigma-Aldrich
Paroxetine maleate salt, ≥98% (HPLC), solid