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  • Use of bioresorbable membranes to reduce abdominal and perihepatic adhesions in 2-stage hepatectomy of liver metastases from colorectal cancer: results of a prospective, randomized controlled phase II trial.

Use of bioresorbable membranes to reduce abdominal and perihepatic adhesions in 2-stage hepatectomy of liver metastases from colorectal cancer: results of a prospective, randomized controlled phase II trial.

Annals of surgery (2013-02-22)
Aurélien Dupré, Anne Lefranc, Emmanuel Buc, Jean Robert Delpero, François Quenet, Guillaume Passot, Serge Evrard, Michel Rivoire
ABSTRACT

To assess by prospective randomized controlled trial the feasibility and efficacy of using a bioresorbable hyaluronic acid/carboxymethylcellulose membrane (HA membrane) to prevent abdominal and perihepatic adhesions in metastatic colorectal cancer patients requiring 2-stage hepatectomy. Two-stage hepatectomy offers the possibility of long-term survival to selected patients whose liver metastases cannot be removed in a single procedure. However, the second operation is made more difficult by adhesions arising from the first. HA membrane reduces adhesions in gynecologic and abdominal surgery but this is the first trial in hepatectomy. Fifty-four candidates for 2-stage hepatectomy were randomized at the end of the first procedure to implantation of HA membrane (n = 41) or standard management (n = 13). Thirty patients from the membrane arm and 11 well-matched controls underwent the planned second hepatectomy. Positioning of the HA membranes was feasible in all but one patient and did not increase complications associated with the first hepatectomy. At second hepatectomy, patients in the HA membrane arm required 33% less time than controls to achieve complete liver mobilization (median: 50 vs 75 minutes; primary endpoint). The risk of extensive adhesions was reduced in the HA membrane group (31% had grade 3-4 adhesions vs 55% in controls), as was adhesion severity (17% thick and hypervascular adhesions vs 46%). The proportion of patients with complications at second hepatectomy was higher in the control group (55% vs 23% in the HA membrane group, P = 0.07). Use of 4 HA membranes at the end of first hepatectomy reduced the extent and severity of adhesions and facilitated the second hepatectomy in patients with liver metastases who required a 2-stage hepatectomy. A larger study to confirm these findings is warranted. (NCT01262417).

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Carboxymethylcellulose sodium, meets USP testing specifications, Medium viscosity
Sigma-Aldrich
Sodium carboxymethyl cellulose, average Mw ~250,000, degree of substitution 0.7
Sigma-Aldrich
Sodium carboxymethyl cellulose, average Mw ~250,000, degree of substitution 0.9
Sigma-Aldrich
Sodium carboxymethyl cellulose, average Mw ~700,000
Sigma-Aldrich
Sodium carboxymethyl cellulose, average Mw ~250,000, degree of substitution 1.2
Sigma-Aldrich
Sodium carboxymethyl cellulose, viscosity 50-200 cP , c=4% H2O at 25­°C
Sigma-Aldrich
Carboxymethylcellulose sodium salt, SAJ first grade
Sigma-Aldrich
Carboxymethylcellulose sodium salt, Medium viscosity
Sigma-Aldrich
Carboxymethylcellulose sodium salt, low viscosity
Sigma-Aldrich
Carboxymethylcellulose sodium salt, High viscosity