SAB4504536

Anti-phospho-Src (pTyr⁴¹⁸) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-ASV, Anti-SRC1, Anti-THC6, Anti-c-SRC, Anti-p60-Src
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 59 kDa
• species reactivity: human, mouse, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P12931
• UniProt accession no.: P12931
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr418)
• Gene Information: human ... SRC(6714)

Description

General description

SRC (proto-oncogene, non-receptor tyrosine kinase) belongs to the Src family kinases (SFKs). It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. This gene is located on human chromosome 20q11.

Immunogen

The antiserum was produced against synthesized peptide derived from human Src around the phosphorylation site of Tyr418.

Immunogen Range: 386-435

Application

Anti-phospho-Src (pTyr418) antibody has been used in immunofluorescence.

Biochem/physiol Actions

SRC (proto-oncogene, non-receptor tyrosine kinase) controls early HIV-1 (human immunodeficiency virus 1) infection post-entry. This gene participates in fundamental physiological and pathological processes like carcinogenesis and tumor progression. Src kinase activity helps in the migration of endothelial cells.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable