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  • Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.

Dietary vitamin K1 and stability of oral anticoagulation: proposal of a diet with constant vitamin K1 content.

Thrombosis and haemostasis (1997-03-01)
S L Booth, J M Charnley, J A Sadowski, E Saltzman, E G Bovill, M Cushman
ABSTRACT

Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1 equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

MATERIALS
Product Number
Brand
Product Description

Supelco
Phylloquinone (K1), analytical standard
Sigma-Aldrich
Vitamin K1, viscous liquid
Phytomenadione, European Pharmacopoeia (EP) Reference Standard
Supelco
Phytonadione, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Vitamin K1, BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers