204883

Complement C1-Esterase Inhibitor, Human

Complement C1-Esterase Inhibitor, Human, is a native, single-chain glycoprotein that is involved in regulation of complement, coagulation, fibrinolytic and contact systems of circulating plasma.

• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• does not contain: preservative
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• impurities: IgG, IgA, IgM, albumin, C3, C4, or ceruloplasmin, trace
• shipped in: wet ice
• storage temp.: −70°C

Description

General description

Native, human C1-esterase. Complent C1-esterase inhibitor purified from human plasma. Single chain glycoprotein present in normal human serum at a concentration of 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. It is the only known inhibitor of activated C1r and C1s complement enzymes. Persons with either hereditary or acquired deficiencies of C1 esterase inhibitor are susceptible to recurrent attacks of angioedema.

Native, human C1-esterase. Single-chain glycoprotein present in normal human serum at 180 µg/ml. Involved in regulation of complement, coagulation, fibrinolytic and contact (kinin-forming) systems of circulating blood plasma. The only known inhibitor of activated C1r and C1s complement enzymes. The presence of either hereditary or acquired deficiencies of C1 inhibitor produce susceptibility to recurrent attacks of angioedema.

Biochem/physiol Actions

≥80% of C1-esterase inhibitor will bind activated C1s.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In PBS, pH 7.4, sterile-filtered through a 0.22 µm filter.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Bowen, B., et al. 2001. Clin. Immunol.98, 157.
Davis, A.E. 1988. Ann. Rev. Immunol. 6, 595.

Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable