- Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells.
Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells.
Molecular pharmacology (2017-08-06)
Emilia Kansanen, Suvi M Kuosmanen, Anna-Kaisa Ruotsalainen, Heidi Hynynen, Anna-Liisa Levonen
PMID28778983
ABSTRACT
Nitro-fatty acids are reactive signaling mediators that are formed when unsaturated fatty acids react with nitric oxide or nitric oxide-derived species. Nitro-fatty acids can modify specific signaling pathways via post-translational modifications of Cys residues in key regulatory proteins. One of the signaling cascades activated by nitro-fatty acids is the Keap1-Nrf2 pathway. We have previously studied the effects of nitro-oleic acid (OA-NO
MATERIALS