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An update of recent clinical trials examining adapalene and acne.

Journal of the European Academy of Dermatology and Venereology : JEADV (2002-02-15)
J E Wolf
ABSTRACT

Topical retinoids are a mainstay in the treatment of acne vulgaris. In the past these agents have been associated with irritant effects, however, newer generations of topical retinoids have emerged that have been designed to be less irritating. This paper focuses on the newer topical retinoid products, and specifically looks at adapalene and recent clinical studies that evaluate its efficacy and tolerability. Most of these studies evaluate adapalene in comparison with the new tretinoin formulations, which, like adapalene, have been designed to be less irritating than their predecessors. The various studies comparing the efficacy and tolerability of adapalene with the new formulations of tretinoin are described. A summary of the findings and their implications follows.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Adapalene, ≥98% (HPLC)
Adapalene for peak identification, European Pharmacopoeia (EP) Reference Standard
Adapalene, European Pharmacopoeia (EP) Reference Standard
USP
Adapalene, United States Pharmacopeia (USP) Reference Standard
Supelco
Adapalene, Pharmaceutical Secondary Standard; Certified Reference Material